简介：　　

谢海侠，女，博士，研究员。1999年获华中农业大学学士学位，2005年获中国科学院水生生物研究所理学博士学位。2005年-2007年于新加坡国立大学生物系接受博士后培训，主要开展迟缓爱德华氏菌Ⅲ型分泌系统的致病机理研究。2010年3月―7月于伦敦帝国理工学院微生物系开展合作交流。研究兴趣包括：病原菌与宿主的相互作用；毒力岛Ⅲ型分泌系统的分子致病机理，以及毒力岛Ⅵ型分泌系统的分子致病机理。在研/完成的国家自然科学基金面上项目有：“杀鱼爱德华氏菌Ⅲ型分泌系统输送器蛋白的分子致病机理研究”、“鲶爱德华氏菌多拷贝质粒pEI1和pEI2编码的毒力蛋白的分子致病机理研究”以及“鲶爱德华氏菌Ⅲ型与Ⅵ型分泌系统致病的分子机制研究”

代表性论文（* 通讯作者，# 并列作者）

Yi Jia, Xiao Shui Bing, Zeng Zhi Xiong, Lu Jin Fang, Liu Lu Yi, Laghari Zubair Ahmed, Nie Pin, Yu Hong Bing, Xie Hai Xia*. EseE of Edwardsiella tarda augments the secretion of translocon protein EseC and the expression of escC-eseE operon. Infect Immun. 2016, doi:10.1128/IAI.00106-16.

Zhou Ying, Liu Lu Yi, He Tian Tian, Laghari Zubair Ahmed, Nie Pin, Gao Qian, Xie Hai Xia*. Edwardsiella tarda EsaE (Orf19 protein) is required for the secretion of type III substrates, and pathogenesis in fish. Vet Microbiol. 2016, 190:12-18.

Lu Jin Fang, Wang Wei Na, Wang Gai Ling, Zhang He, Zhou Ying, Gao Zhi Peng, Nie Pin*, Xie Hai Xia*. Edwardsiella tarda EscE (Orf13 protein) is a type III secretion system secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infect Immun. 2016, 84:2-10.

Gao Zhi Peng, Nie Pin, Lu Jin Fang, Liu Lu Yi, Xiao Tiao Yi, Liu Wei, Liu Jia Shou*, Xie Hai Xia*. Type III secretion system translocon component EseB forms filaments and mediates autoaggregation and biofilm formation in Edwardsiella tarda. Appl Environ Microbiol. 2015, 81:6078-6087.

Xie Hai Xia#, Lu Jin Fang#, Zhou Ying, Yi Jia, Yu Xiu-Jun*, Leung Ka Ying, Nie Pin*. Identification and functional characterization of the novel Edwardsiella tarda effector EseJ. Infect Immun. 2015, 83:1650-1660.

Xie Hai Xia, Lu Jin Fang, Rolhion Nathalie, Holden David W., Nie Pin*, Zhou Ying, Yu Xiu-Jun*. Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infect Immun. 2014, 82:3436-3445.

Zhao Li Juan, Lu Jin Fang, Nie Pin*, Li Ai Hua, Xiong Bang Xi, Xie Hai Xia*. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Vet Microbiol. 2013, 166:233-41.

Hai Xia Xie, Hong Bing Yu, Jun Zheng, Leonard J. Foster, Yu-Keung Mok, Brett B. Finlay, Pin Nie, Ka Yin Leung. EseG, an effector of the type III secretion system of Edwardsiella tarda triggers microtubule destabilization. Infect Immun. 2010, 78:5011-5021.

Xie Hai Xia, Nie Pin, Zhang Yong An, Sun Bao Jian, Sun Jun, Yao Wei Jian, Gao Qian. Histological and cytological studies on the developing thymus of mandarin fish Siniperca chuatsi (Perciformes: Teleostei). J Appl Ichthyol. 2006, 22:125-131.

Xie Hai Xia, Nie Pin, Chang Ming Xian, Sun Bao Jian. Cloning and characterization of the glycosaminoglycan-degrading enzyme chondroitin AC lyase from Flavobacterium columnare G4. Arch Microbiol. 2005, 184:49-55.

Xie Hai Xia, Nie Pin, Sun Bao Jian. Characterization of two membrane-associated protease genes obtained from screening out-membrane protein genes of Flavobacterium columare G4. J Fish Dis. 2004, 27:719-729.